You remind me of a Carolina Reaper, one is a compact spicy sadist that drains tears from it's victims and the another one is a pepper.
I remember someone literally solo'd the Shuffling Horror with a leper simply because it got virtue instead of affliction. Dude regenerates like crazy.
I heard that now you can lose the virtue.(didn't see it happen yet) I don't know if that guy played the old version where max stress is 100 and not 200 (100 stress is same as before, between 100 and 200 you have a chance to get your hp reduced to 0 and reach 200 is instant death without death's door check).